Mother-to-Child HIV Transmission

HIV-1 endocytosis linked to virus gene expression in polarized trophoblasts

Published in AIDS Weekly, January 3rd, 2005

HIV research specialists report finding "a correlation between endocytic uptake of HIV-1 and virus gene expression in polarized trophoblasts."

"Vertical transmission of human immunodeficiency virus type 1 (HIV-1) is the primary cause of infection by this retrovirus in infants. ... To shed light on the relationship between endocytosis and the fate of HIV-1 in polarized trophoblasts, the step-by-step movements of HIV-1 within the endocytic compartments were tracked by confocal imaging," wrote G. Vidricaire and colleagues, CHU Laval, Research Center for Infectious Diseases, Quebec City.

"Incoming virions were initially located in early endosomes. As...

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Source: AIDS Weekly (2005-01-03)

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