HIV/AIDS-Associated Infection

Saquinavir & miconazole synergistic against C. albicans & C. neoformans

Published in AIDS Weekly, January 24th, 2005

Saquinavir and miconazole are synergistic against Candida albicans/C. neoformans.

"Candidiasis and cryptococcosis are the most common fungal diseases among patients suffering from HIV infection. In the present work we assess whether the combined therapies, proteinase inhibitors and antimycotic drugs, could modify the therapeutic effect of antimycotics.

"An in vitro study to evaluate the antifungal effect of saquinavir and antimycotic drugs combination on yeast growth was performed. Strains of C. albicans and C. neoformans from HIV-seropositive patients were used," wrote investigators in Italy.

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Source: AIDS Weekly (2005-01-24)

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