HIV/AIDS Research
Evidence found for positive epistasis in HIV-1
Published in AIDS Weekly, January 31st, 2005
"Reproductive strategies such as sexual reproduction and recombination that involve the shuffling of parental genomes for the production of offspring are ubiquitous in nature.
"However, their evolutionary benefit remains unclear. Many theories have identified potential benefits, but progress is hampered by the scarcity of relevant data," scientists in Switzerland report.
"One class of theories is based on the assumption that mutations affecting fitness exhibit negative epistasis. Retroviruses recombine frequently and thus provide a unique opportunity to test these theories," wrote...
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Source: AIDS Weekly (2005-01-31)
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