HIV/AIDS Therapy

Lopinavir plasma concentrations higher when combined with valproic acid

Published in AIDS Weekly, January 31st, 2005

Lopinavir plasma concentrations are higher when combined with valproic acid.

According to recent research from the United States, "Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine if VPA affects the plasma concentration of efavirenz (EFV) or lopinavir.

"HIV type 1 (HIV-1)-infected patients receiving EFV or lopinavir-ritonavir (LPV/r) had 9 or 10 blood samples drawn over 8 to 24 hours of a dosing interval at steady state before and after receiving 250 mg of VPA twice daily for 7 days."

"VPA blood...

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Source: AIDS Weekly (2005-01-31)

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