Published in AIDS Weekly, January 31st, 2005
According to recent research from the United States, "Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine if VPA affects the plasma concentration of efavirenz (EFV) or lopinavir.
"HIV type 1 (HIV-1)-infected patients receiving EFV or lopinavir-ritonavir (LPV/r) had 9 or 10 blood samples drawn over 8 to 24 hours of a dosing interval at steady state before and after receiving 250 mg of VPA twice daily for 7 days."
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