HIV/AIDS Pathogenesis
Conserved residues in HIV-1 gp41 coiled-coil pocket essential for replication
Published in AIDS Weekly, February 14th, 2005
"The human immunodeficiency virus type 1 (HIV-1) gp41 plays an important role in mediating the fusion of HIV with host cells. During the fusion process, three N-terminal helices and three C-terminal helices pack in an anti-parallel direction to form a six-helix bundle.
"X-ray crystallographic analysis of the gp41 core demonstrated that within each coiled-coil interface, there is a deep and large pocket, formed by a cluster of residues in the N-helix coiled coil," researchers in the United States wrote.
"In this report," said H.M. Mo and...
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Source: AIDS Weekly (2005-02-14)
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