HIV/AIDS Drug Resistance
K65R mutations correlate negatively with thymidine analogue mutations
Published in AIDS Weekly, February 14th, 2005
"Over the past 5 years, 1846 HIV-infected patients underwent drug resistance testing at our institution. None out of 216 drug-naive subjects showed K65R," scientists writing in the journal AIDS report.
"However," said L. Valer and coauthors, "it was recognized in 53 out of 1630 antiretroviral-experienced patients (3.3%), of whom 10 had never been exposed to tenofovir.
"The rate of K65R increased from 0.6% in 1999 to 11.5% in 2004. The recognition of K65R correlated negatively with the presence of thymidine analogue mutations but positively...
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Source: AIDS Weekly (2005-02-14)
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