HIV/AIDS Research
Peptides specifically binding to HIV-1 psi RNA selected/characterized
Published in AIDS Weekly, February 21st, 2005
According to recent research from South Korea, "The packaging of HIV genomic RNA is mediated by a specific interaction between a nucleocapsid (NC) protein and packaging signal (psi, psi) RNA sequence.
"However, this interaction can be inhibited by the presence of peptides or proteins that specifically bind to the psi sequence. The 125-base-long RNA comprises a specific secondary structure that can be recognized by certain peptide sequences."
"Accordingly, the current study presents a method for selecting such peptides from a phage-displayed peptide...
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Source: AIDS Weekly (2005-02-21)
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