Published in AIDS Weekly, February 21st, 2005
Study 1: Amdoxovir plus inosine monophosphate dehydrogenase inhibitors are active against wild-type and drug-resistant HIV-1 variants.
According to a study from the United States, "Amdoxovir [(-)-beta-D-2,6-diaminopurine dioxolane (DAPD)] is a nucleoside analogue reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.
"DAPD is deaminated by adenosine deaminase to the guanosine analogue dioxolane guanosine (DXG), which is subsequently phosphorylated to the corresponding 5' triphosphate (DXG-TP)....
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