Kaposi Sarcoma-Associated Herpesvirus
Cidofovir used to provide insight into KSHV replication and pathogenesis
Published in AIDS Weekly, February 28th, 2005
"Treatment of primary effusion lymphoma cells latently infected by Kaposi's sarcoma-associated herpesvirus (KSRV; human herpesvirus-8 [HHV-8]) with agents such as 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a lytic viral replication cycle, with an ordered gene expression program.
"Initial studies of the KSHV expression program following TPA induction using viral microarrays yielded useful information concerning the viral expression program, but precise kinetic assignments for some genes remained unclear. Classically, late herpesvirus genes require viral DNA...
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Source: AIDS Weekly (2005-02-28)
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