HIV/AIDS Pathogenesis
HIV-1 Nef does not significantly affect viral infectivity in target cells
Published in AIDS Weekly, March 14th, 2005
According to recent research from Japan, "The impact of human immunodeficiency virus type 1 (HIV-1) Nef on viral infectivity was evaluated by characterization of chimeric clones."
"Chimera with respect to the nef gene were constructed between subtypes B and C, and monitored for their replication in human peripheral blood mononuclear cells.
"The parental clones used were pNL432 (subtype B) and pIndie-C1 (Indian subtype C), which show considerable sequence heterogeneity in nef and distinct viral Growth phenotype," A. Jere and colleagues reported.
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Source: AIDS Weekly (2005-03-14)
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