HIV/AIDS Therapy
Large difference in cervicovaginal penetration among antiretroviral agents
Published in AIDS Weekly, March 14th, 2005
"The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) is likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and postexposure prophylaxis regimens.
"This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution," scientists writing in the Journal of Acquired Immune Deficiency Syndromes report.
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Source: AIDS Weekly (2005-03-14)
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