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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . March 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

HIV/AIDS Pathogenesis - HIV-specific CTLs from long-term survivors select a unique T cell receptor

HIV/AIDS Prevention - High mobility among rural-urban migrants associated with increased sexual risk

HIV/AIDS Therapy - Protease inhibitors impair glucose-stimulated insulin secretion from beta cells

Reverse Transcriptase - AZT 5'-triphosphate mimics inhibit HIV reverse transcriptase

Aspergillosis - EIA/qPCR used to diagnose invasive aspergillosis in high-risk patients

Assisted Reproduction - IVF/ICSI safely avoids disease transmission in HIV-1 serodiscordant couples

Assisted Reproduction - Sperm washing techniques are safe, may address fertility needs of HIV+ men

At-Risk Populations - FTM transgender people more likely to partake in high risk sexual activity

Business & Finance - Anti-infectives focused company gets NASDAQ extension on listing requirements

Business Update - Biopharma company signs agreement with Celliance BioServices, Inc.

HIV/AIDS Research - Findings advance knowledge in HIV/AIDS research

Cancer Research - Reolysin clinical trial approved by U.K. regulatory authorities

Cell Biology - Virologists illuminate HIV cell activity

Cholera - Study finds cholera vaccine effective

Cryptococcus Diagnostics - RT-PCR assay detects and quantitates Cryptococcus neoformans

Diagnostics - Cartridge system facilitates reagent delivery to microfluidic devices

Diagnostics - Two HIV rapid tests submitted to the U.S.FDA for PMA

Domestic Violence - Women in abusive relationships with HIV+ men are at risk of infection

Drug Resistance - Researchers' work adds to drug resistance body of knowledge

Finance - COLD-EEZE manufacturer reports financial results

Finance - Infection- and cancer-focused company reports year end 2004 financial results

Finance - Pharma company announces record financial results

Finance - Vaccine-focused biopharmaceutical company announces FY 2004 financial results

HIV/AIDS Coinfection -  Schistosoma mansoni/HIV-1 coinfection leads to CD4 cell reduction

HIV/AIDS Coinfection - CD4 counts higher in HIV-positive patients infected with Helicobacter pylori

HIV/AIDS Diagnosis - Dual testing better for monitoring new cases of HIV

HIV/AIDS Diagnosis - NAAT test detects HIV more effectively than standard tests in urban study

HIV/AIDS Diagnostics - Real-time PCR rapidly discriminates between HIV-2 genotypes A and B

HIV/AIDS Drug Side Effects - Mitochondrial pathogenesis in AIDS due to NRTI-induced DNA polymerase inhibition

HIV/AIDS Encephalitis - Increased FKBP12 may explain vulnerability of basal ganglia to HIV infection

HIV/AIDS Epidemiology - HIV infection rate among blacks doubles

HIV/AIDS Epidemiology - New HIV strain has very deadly aspects

HIV/AIDS Funding - Nebraska receives $1.7 million for AIDS programs

HIV/AIDS Infection - Influence of host genetic variation on susceptibility to HIV type 1 infection

HIV/AIDS Mental Health - Factors associated with victimization of African American female DUs identified

HIV/AIDS Mental Health - Substance P has role in pathophysiology of stress/depression in HIV infection

HIV/AIDS Neurology - CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

HIV/AIDS Pathogenesis - Acute SIV brain infection leads to upregulation of IL6 ad IFN-regulated genes

HIV/AIDS Pathogenesis - Amyloid precursor protein may facilitate monocyte entry into brain

HIV/AIDS Pathogenesis - Conformational flexibility retained in HIV-1 Rev-RNA complexes

HIV/AIDS Pathogenesis - LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase

HIV/AIDS Pathogenesis - MCP-1-2578G allele associated with elevated MCP-1 in cerebrospinal fluid

HIV/AIDS Pathogenesis - Macrophage-secreted MMP 9 is down-regulated following HIV-1 infection

HIV/AIDS Pathogenesis - Soluble toll-like receptor 2 associated with progression of HIV infection

HIV/AIDS Pathogenesis - Ubiquitinated histone H1B is a cofactor to HIV-1 resistance factor

HIV/AIDS Pathogenesis - Urokinase plasminogen activator receptor important in HIV-associated dementia

HIV/AIDS Pediatrics - HAART should be initiated in symptomatic children aged 12 months or older

HIV/AIDS Prevention - Fear of test result and stigmatization are barriers to HIV testing in Bali

HIV/AIDS Prevention - HIV/AIDS risk perception predicted among low-income/urban/older adults

HIV/AIDS Prevention - Preliminary safety data from phase 1 HIV vaccine trial reported

HIV/AIDS Prevention - Rural Malawians publicly discuss strategies for HIV prevention

HIV/AIDS Prevention - Sexual compulsivity scores associated with risky sexual behavior frequency

HIV/AIDS Prevention - Youth with HIV take more risks after new meds introduced

HIV/AIDS Research - Data advance knowledge in HIV/AIDS research

HIV/AIDS Research - Tissue culture model analyzes macrophage activation in the brain

HIV/AIDS Testing - Expectant mothers urged to get tested for AIDS

HIV/AIDS Therapy - Antiretroviral enfuvirtide is not an inhibitor of p450 cytochrome

HIV/AIDS Therapy - Archival virus still necessitates life-long antiretroviral therapy

HIV/AIDS Therapy - Changes in clinical progression to aids in patients on HAART therapy

HIV/AIDS Therapy - Enfuvirtide improves health-related quality of life in HIV-infected patients

HIV/AIDS Therapy - HAART adherence is the most relevant factor for virological success

HIV/AIDS Therapy - HPLC/UV method suitable for pharmacokinetics of abacavir in plasma

HIV/AIDS Therapy - Molecular basis determined for GLUT4 inhibition by protease inhibitors

HIV/AIDS Therapy - Protein found in cells may be the key to controlling HIV

HIV/AIDS Therapy - Studies add new findings to HIV/AIDS therapy body of knowledge

HIV/AIDS Transmission - Older macaque infants are more susceptible than neonates to SHIV 89.6P

HIV/AIDS Transmission - Study describes differences in transmission of HIV between males, females

HIV/AIDS Vaccine - Anti-HIV antibodies require few residues to neutralize HIV-1

HIV/AIDS Vaccine - Antibodies to HIV vif turns HIV infection into benign problem

HIV/AIDS Vaccine - Antibody response elicited by trimeric HIV glycoproteins analyzed

HIV/AIDS Vaccine - Clinical evaluation of HIV/AIDS vaccine initiatied

HIV/AIDS Vaccine - Differential immune containment of HIV-1 clade B strains found

HIV/AIDS Vaccine - Expression of gag protein of HIV-1CN in Pichia pastoris reported

HIV/AIDS Vaccine - HIV-1 virus-like particles are potent immune stimulators

HIV/AIDS Vaccine - Inactivated HIV antigen plus CpG ODN protects against infection

HIV/AIDS Vaccine - Inducing murin CCR5-downregulating antibodies prevents HIV infection

HIV/AIDS Vaccine - Macaque MHC molecules presenting immunodominant SIV epitopes analyzed

HIV/AIDS Vaccine - Modified HIV envelope proteins exhibit enhanced binding to antibodies

HIV/AIDS-Associated Dementia - Antibody markers identified in HIV-associated dementia

HIV/AIDS-Associated Dementia - Blood-brain barrier compromise has role in pathogenesis of HIV-related dementia

HIV/AIDS-Associated Dementia - HIV dementia risk is associated with apolipoprotein E4 in older persons

HIV/AIDS-Associated Dementia - Oxidative stress markers increased in actively progressive HIV dementia

HIV/AIDS-Associated Infection - Severe respiratory disease necessitating hospitalization decreased in HAART era

HIV/AIDS-Related Dementia - Brain water diffusion contributes to cognitive deficits in HIV infection

HIV/AIDS-Related Dementia - CD14+ macrophage hybrid phenotype circulates in persons with high HIV viral load

HIV/AIDS-Related Dementia - HIV dementia is an evolving disease

HIV/AIDS-Related Lipodystrophy - F-18-fluorodeoxyglucose PET visualizes lipodystrophy in HIV-infected patients

Health Promotion - Online toolkit will inform caregivers of people living with HIV/AIDS

Human Herpesvirus 6 - Article examining Human Herpesvirus 6 published in leading journal

Immunology - Persistence of virus escape variants described

Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed

Legal Issues - Justices again to consider if fear of HIV exposure warrants lawsuit

Leishmaniasis - Promising visceral leishmaniasis treatments must translate into actual therapy

Malaria - Biotechnology corporation initiates pediatric antimalaria trial

Malaria Diagnostics - Diagnostics company developes rapid test kit for malaria, expands TB testing

Mergers & Acquisitions - Dermal Defense acquires marketing rights for antimicrobial hand sanitizer

Mergers & Acquisitions - Pharma company to acquire Idun Pharmaceuticals

Microbiology - Genetic fingerprints uncover emerging medically important filamentous fungi

Patents - Technology company granted artificial liver device patent

Philanthropy - U.N. health body welcomes Canadian gift

Retroviral Infection - Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML

SARS Coronavirus - RT-PCR distinguishes SARS coronavirus from other respiratory tract infections

Sexual & Reproductive Health - Topical treatment shown to inhibit HIV and herpes simplex virus infection

Sexually Transmitted Diseases - Funding affects incidence of sexually transmitted diseases

Smallpox Vaccine - Smallpox vaccine does not protect macaques with AIDS from monkeypox

Tuberculosis - Genotypic/phenotypic heterogeneity among M. tuberculosis isolates determined

Virology - Hepatitis C virus genotype influences HIV and HCV progression

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