Pneumocystis Infection

Neonatal lungs lack maturation factors for efficient cellular functioning

Published in AIDS Weekly, April 4th, 2005

"Clearance of Pneumocystis carinii f. sp. muris (PC) organisms from the lungs of neonatal mice is delayed due to failure of initiation of inflammation over the first 3 weeks after infection.

"The ability of neonatal lung CD11c+ dendritic cells (DCs) to induce Ag-specific T cell proliferative responses was significantly reduced compared with adult lung DCs. However, neonatal bone marrow-derived DCs were as competent at presenting PC Ag as were adult bone marrow-derived DCs," researchers in the United States report.

"Because GM-CSF mRNA expression and activity were significantly reduced in neonatal lungs compared with adults," said M.H. Qureshi...

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Source: AIDS Weekly (2005-04-04)

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