HIV/AIDS Epidemiology

Low CCR5Delta32 frequency related to higher susceptibility to HIV-1 infection

Published in AIDS Weekly, April 11th, 2005

Low CCR5Delta32 frequency may be related to a higher genetic susceptibility to HIV-1 infection in Iranians.

According to a study from Iran, "Host genetic control of HIV infection involves certain polymorphisms of some chemokine receptor genes that are associated with susceptibility and progression of HIV-1 infection.

"Recent data suggest that two important polymorphisms in CCR2 and CCR5 chemokine receptors, CCR5Delta32 and CCR2-64I, prevent HIV transmission and delay disease progression. In this study allele and haplotype frequencies of the CCR5Delta32 and CCR2-64I mutations were determined in southern Iranian normal population using PCR and PCR...

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Source: AIDS Weekly (2005-04-11)

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