HIV/AIDS Research

APOBEC3-edited HIV G->A hypermutants recovered by PCR method

Published in AIDS Weekly, April 11th, 2005

APOBEC3-edited HIV G->A hypermutants was recovered by a PCR method.

"Virus genomes from the same family may exhibit a wide range in their DNA GC content, whereas viral hypermutants differ substantially in GC content from their parental genomes," researchers in France report.

"As AT-rich DNA melts at lower temperatures than GC-rich DNA, use of a lower denaturation temperature during PCR should allow differential amplification of AT-rich genomes; or variants within a quasispecies.

"The latter situation has been explored explicitly in a two-step process by using a series of well-defined viral sequences differing in their AT...

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Source: AIDS Weekly (2005-04-11)

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