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HIV/AIDS Adverse Drug Reaction

Reactive metabolites cause drug reactions to sulfonamides in HIV infection

Published in AIDS Weekly, April 25th, 2005

Reactive metabolites cause adverse drug reactions to sulfonamides in HIV infection.

According to a study from Canada, "Hypersensitivity adverse drug reactions are much more common among patients with acquired immunodeficiency syndrome (AIDS) than in the general population. High rates of hypersensitivity reactions to clindamycin have been noted.

"To investigate the role of reactive metabolites in these reactions, the authors studied toxicity of clindamycin and sulphamethoxazole (SMX) and their metabolites in uninfected and human immunodeficiency virus (HIV)-infected MOLT3 cells."

"Infected and uninfected cells were incubated with...

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