Immunology

Sex-based differences in T-lymphocyte responses found in HIV-1+ people

Published in AIDS Weekly, April 25th, 2005

According to a study from the United States, "Sex-based differences in the levels of human immunodeficiency virus 1 (HIV-1) RNA in plasma could be associated with differences in the strength of HIV-1 specific CD8+ T-cell responses."

T.R. Sterling and colleagues, Vanderbilt University, tested this hypothesis by comparing the T-lymphocyte responses at different times in a group of HIV-1 positive men and women.

"CD8+ effector responses in 18 men and 15 women were measured 0-2 years (time A) and 5-7 years (time B) after seroconversion. CD8+ effector responses were seen in 7 (39%) of 18 men and 2 (13%) of 15 women at time A (p=.13) and in 12 (67%) of 18...

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Source: AIDS Weekly (2005-04-25)

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