HIV/AIDS Drug Development
High-throughput modified ELISA screens HIV-1 pg41 fusion inhibitors
Published in AIDS Weekly, May 9th, 2005
According to recent research published in the Journal of Biomolecular Screening, "The HIV-1 envelope glycoprotein transmembrane subunit, gp41, mediates the fusion of viral and target cell membranes.
"The 2 helical regions in the ectodomain of gp41, the N-helix and the C-helix, form a helical bundle complex that has been suggested as a fusion-active conformation. Previously, an enzyme-linked immunosorbent assay (ELISA) method had been established to measure the interaction of 2 helical regions of gp41."
"In this study," reported B.S. Jin and colleagues at...
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Source: AIDS Weekly (2005-05-09)
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