HIV/AIDS Pathogenesis
HIV-1 Vpr binds to 14-3-3 proteins and facilitates complex formation with Cdc25C
Published in AIDS Weekly, May 9th, 2005
According to a study from the United States, "Vpr and selected mutants were used in a Saccharomyces cerevisiae two-hybrid screen to identify cellular interactors. We found Vpr interacted with 14-3-3 proteins, a family regulating a multitude of proteins in the cell. Vpr mutant R80A, which is inactive in cell cycle arrest, did not interact with 14-3-3."
"14-3-3 proteins regulate the G(2)/M transition by inactivating Cdc25C phosphatase via binding to the phosphorylated serine residue at position 216 of Cdc25C. 14-3-3 overexpression in human cells synergized with Vpr...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2005-05-09)
More Articles from AIDS Weekly
- HIV/AIDS Drug Development
High-throughput modified ELISA screens HIV-1 pg41 fusion inhibitors - HIV/AIDS Drug Development
Sulfonated naphthyl porphyrins active against HIV-1 - HIV/AIDS Mental Health
Apathy correlates with cognitive function but not CD4 status in HIV infection - HIV/AIDS Pathogenesis
B30.2(SPRY) domain is the major determinant of anti-HIV-1 potency - HIV/AIDS Vaccine
Anti-HIV Abs induced to control viremia via complement-mediated inactivation - Bioterrorism
Construction company responds to airborne infectious disease isolation needs - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
