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HIV/AIDS Therapy

Mutations in HIV subtypes must be better understood to prevent resistance

Published in AIDS Weekly, May 9th, 2005

Studying mutations in HIV-1 is important for understanding resistance to antiretroviral drugs.

In a paper in PLoS Medicine, a worldwide collaboration of HIV researchers looked at the mutations found in more than 3000 people infected with non-subtype-B HIV-1 - the most common HIV-1 subtype globally. They compared the mutations with those found in over 4500 people with subtype B infections - the most common in the developed world and the subtype that most HIV drugs have been targeted against.

Reassuringly, they found few novel mutations in non-subtype-B viruses exposed to the current antiretroviral drugs and concluded that the present focus on...

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