Kaposi Sarcoma-Associated Herpesvirus
KSHV LANA protects lymphoid cells from p16 INK4A-induced cell cycle arrest
Published in AIDS Weekly, May 9th, 2005
According to recent research from the United States, "Latently infected Kaposi's sarcoma-associated herpesvirus (KSHV)-associated tumor cells have both endothelial and lymphoid origins and express a limited set of latent viral genes.
"One such gene, ORF73, encodes the latency-associated nuclear antigen (LANA), a multifunctional protein that plays roles in viral DNA replication, episome maintenance, and transcriptional regulation. LANA interacts with cellular proteins involved in transcriptional regulation such as the tumor suppressors, retinoblastoma (Rb) and p53, and RING3...
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Source: AIDS Weekly (2005-05-09)
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