HIV/AIDS Pathogenesis
B30.2(SPRY) domain is the major determinant of anti-HIV-1 potency
Published in AIDS Weekly, May 9th, 2005
According to recently published research from the United States, "Retroviruses encounter dominant postentry restrictions in cells of particular species.
"Human immunodeficiency virus type 1 (HIV-1) is blocked in the cells of Old World monkeys by TRIM5alpha, a tripartite motif (TRIM) protein composed of RING, B-box 2, coiled-coil, and B30.2(SPRY) domains. Rhesus monkey TRIM5alpha (TRIM50alpha(rh)) more potently blocks HIV-1 infection than human TRIM5alpha (TRIM5alpha(hu))."
"Here, by studying chimeric TRIM5alpha proteins, we demonstrate that the major determinant of...
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Source: AIDS Weekly (2005-05-09)
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