Published in AIDS Weekly, May 9th, 2005
According to recently published research from the United States, "Retroviruses encounter dominant postentry restrictions in cells of particular species.
"Human immunodeficiency virus type 1 (HIV-1) is blocked in the cells of Old World monkeys by TRIM5alpha, a tripartite motif (TRIM) protein composed of RING, B-box 2, coiled-coil, and B30.2(SPRY) domains. Rhesus monkey TRIM5alpha (TRIM50alpha(rh)) more potently blocks HIV-1 infection than human TRIM5alpha (TRIM5alpha(hu))."
"Here, by studying chimeric TRIM5alpha proteins, we demonstrate that the major determinant of...
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