HIV/AIDS Pathogenesis

HIV-1-associated uracil DNA glycosylase activity essential to HIV-1 life cycle

Published in AIDS Weekly, May 16th, 2005

HIV-1-associated uracil DNA glycosylase activity is essential to the HIV-1 life cycle.

"Uracilation of DNA represents a constant threat to the survival of many organisms including viruses. Uracil may appear in DNA either by cytosine deamination or by misincorporation of dUTP.

"The HIV-1-encoded Vif protein controls cytosine deamination by preventing the incorporation of host-derived APOBEC3G cytidine deaminase into viral particles," scientists writing in the journal Molecular Cell report.

"Here, we show that the host-derived uracil DNA glyosylase UNG2 enzyme, which is recruited into viral particles by the HIV-1-encoded...

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Source: AIDS Weekly (2005-05-16)

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