Published in AIDS Weekly, May 23rd, 2005
"HIV-1 integrase (IN) is an important target for designing new antiviral therapies. Screening of potential inhibitors using recombinant IN-based assays has revealed a number of promising leads including nucleotide analogs such as pyridoxal 5'-phosphate (PLP). Certain PLP derivatives were shown to also exhibit antiviral activities in cell-based assays," researchers in the United States report.
"To identify an inhibitory binding site of PLP to IN," wrote scientists, "we used the intrinsic chemical property of this compound to form a Schiff base with a primary...
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