HIV/AIDS Drug Development

Molecular modeling reveals new HIV-1 IN binding site for nucleotide inhibitor

Published in AIDS Weekly, May 23rd, 2005

Molecular modeling revealed a new HIV-1 integrase binding site for nucleotide inhibitors.

"HIV-1 integrase (IN) is an important target for designing new antiviral therapies. Screening of potential inhibitors using recombinant IN-based assays has revealed a number of promising leads including nucleotide analogs such as pyridoxal 5'-phosphate (PLP). Certain PLP derivatives were shown to also exhibit antiviral activities in cell-based assays," researchers in the United States report.

"To identify an inhibitory binding site of PLP to IN," wrote scientists, "we used the intrinsic chemical property of this compound to form a Schiff base with a primary...

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Source: AIDS Weekly (2005-05-23)

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