HIV/AIDS Research
EcoHIV murine model used to study systemic HIV-1 infection
Published in AIDS Weekly, May 30th, 2005
According to a recently published report from the United States, "We created a model of HIV-1 infection of conventional mice for investigation of viral replication, control, and pathogenesis.
"To target HIV-1 to mice, the coding region of gp120 in HIV-1/NL4-3 was replaced with that of gp80 from ecotropic murine leukemia virus, a retrovirus that infects only rodents."
"The resulting chimeric virus construct, EcoHIV, productively infected murine lymphocytes, but not human lymphocytes, in culture.
"Adult, immunocompetent mice were readily...
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Source: AIDS Weekly (2005-05-30)
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