HIV/AIDS Pathogenesis

JM4 is a four-transmembrane protein binding to CCR5 receptor

Published in AIDS Weekly, June 13th, 2005

Jena-Muenchen 4 is a four-transmembrane protein binding to the CCR5 receptor.

According to published research from Switzerland, "The CC chemokine receptor 5 (CCR5) is a major coreceptor for human immunodeficiency virus (HIV) and CCR5 mutants lacking the carboxy (C)-terminus interfere with HIV infection.

"Therefore, we analyzed the C-terminus of CCR5 and here describe Jena-Muenchen 4 (JM4), a novel CCR5-interacting protein. JM4 is membrane-associated, coprecipitates with CCR5, and is ubiquitously expressed."

"It shares about 62% sequence similarity with JWA and glutamate transporter-associated protein 3-18 (GTRAP3-18), a regulator...

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Source: AIDS Weekly (2005-06-13)

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