HIV/AIDS Pathogenesis
Findings describe new data in HIV/AIDS pathogenesis research
Published in AIDS Weekly, June 27th, 2005
Study 1: HIV-1 Tat stimulates transcription complex assembly through TATA-box-binding protein recruitment in absence of TBP-associated factors.
"The human immunodeficiency virus type I (HIV-1) transactivator protein Tat is an unusual transcriptional activator that is thought to act solely by promoting RNA polymerase II processivity.
"Here we study the mechanism of Tat action by analyzing transcription complex (TC) assembly in vivo using chromatin immunoprecipitation assays. We find, unexpectedly, that like typical activators Tat...
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Source: AIDS Weekly (2005-06-27)
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