Antimicrobial

Hoechst 33258 active against P. carinii/C. albicans/C. dubliniensis

Published in AIDS Weekly, June 27th, 2005

Hoechst 33258 is active against Pneumocystis carinii, Candida albicans and C. dubliniensis.

According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "Hoechst 33258 is a compound that binds nucleic acids.

"We report that Hoechst 33258 exhibits antimicrobial activity against Pneumocystis carinii f. sp. muris in a mouse model for P. carinii pneumonia and against Candida albicans and Candida dubliniensis in vitro."

"Relative to saline treatment," researchers wrote, "a 14-day, daily treatment of mice with 37.5 mg of Hoechst 33258/kg of body...

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Source: AIDS Weekly (2005-06-27)

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