HIV/AIDS Pathogenesis

Nonreplicating HIV-1 contributes to T cell depletion by activating CD4/CD8 cells

Published in AIDS Weekly, July 4th, 2005

Nonreplicating HIV-1 virions contribute to T cell depletion by activating CD4+ and CD8+ T cells.

"Apoptosis of uninfected bystander T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) infection. HIV-1 envelope/receptor interactions and immune activation have been implicated as contributors to bystander apoptosis.

"To better understand the relationship between T-cell activation and bystander apoptosis during HIV-1 pathogenesis, we investigated the effects of the highly cytopathic CXCR4-tropic HIV-1 variant ELI6 on primary CD4+ and CD8+ T cells," scientists in the United States report.

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Source: AIDS Weekly (2005-07-04)

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