HIV/AIDS Pathogenesis
SP1 affects HIV-1 Gag-membrane binding and subsequent events of virus assembly
Published in AIDS Weekly, July 4th, 2005
According to a study from Canada, "The Gag protein of human immunodeficiency virus type 1 (HIV-1) contains a 14-amino-acid region termed SP1 that is located between the capsid (CA) and nucleocapsid (NC) domains. It has been previously observed that either a M368A substitution within SP1 or the Delta SP1 deletion impaired virus production."
"In this study," wrote X.F. Guo and colleagues at Jewish General Hospital in Montreal, we further showed that the M368A point mutation, but not the Delta SP1 deletion, severely diminished the levels of membrane-associated Gag...
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Source: AIDS Weekly (2005-07-04)
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