HIV/AIDS Research
GEP inhibits HIV-1 transcription via Tat without directly binding to cyclin T1
Published in AIDS Weekly, July 4th, 2005
"The cellular positive transcription elongation factor b (P-TEFb), containing cyclin T1 and cyclin-dependent kinase 9 (CDK9), interacts with the human immunodeficiency virus, type 1 (HIV-1) regulatory protein Tat to enable viral transcription and replication. Cyclin T1 is an unusually long cyclin and is engaged by cellular regulatory proteins," investigators in the United States report.
"Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-rich region of cyclin T1 and inhibits P-TEFb function. GEP is composed of...
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Source: AIDS Weekly (2005-07-04)
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