HIV/AIDS Research
Mouse model generates HIV specific human humoral and cellular immune response
Published in AIDS Weekly, July 4th, 2005
According to recent research from Israel, "Lethally irradiated normal BALB/c mice, reconstituted with murine SCID bone marrow and engrafted with human PBMC (Trimera mice), were used to establish a novel murine model for HIV-1 infection. The Trimera mice were successfully infected with different clades and primary isolates of T-and M-tropic HIV-1, with the infection persisting in the animals for 4-6 weeks."
"Rapid loss of the human CD4+ T cells, decrease in CD4/CD8 ratio, and increased T cell activation accompanied the viral infection. All HIV-1 infected animals were...
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Source: AIDS Weekly (2005-07-04)
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