Integrase

HIV-1 integrase-interaction domain studied, chromatin tethering revealed

Published in AIDS Weekly, July 4th, 2005

In a recent study, researchers in the United States reported on the identification of the LEDGF/p75 HIV-1 integrase (IN)-interaction domain, and nuclear localization signal (NLS) reveals NLS-independent chromatin tethering.

"To investigate the basis for the LEDGF/p75 dependence of HIV-1 IN nuclear localization and chromatin association, we used cell lines made stably deficient in endogenous LEDGF/p75 by RNAi to analyze determinants of its location in cells and its ability to interact with IN," wrote M. Vanegas and colleagues, Mayo Clinic.

"Deletion of C-terminal LEDGF/p75 residues 340-417 preserved nuclear and chromatin localization but abolished the...

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Source: AIDS Weekly (2005-07-04)

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