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Human T-Lymphotropic Virus Type 1

CD8+ cells are major determinant of HTLV-1 proviral load

Published in AIDS Weekly, July 4th, 2005

CD8+ cells are a major determinant of HTLV-1 proviral load.

"The CD8+ lymphocyte response is a main component of host immunity, yet it is difficult to quantify its contribution to the control of persistent viruses.

"Consequently, it remains controversial as to whether CD8+ cells have a biologically significant impact on viral burden and disease progression in infections such as human immunodeficiency virus-1 and human T-lymphotropic virus type 1 (HTLV-1)," scientists in England report.

"Experiments to ascertain the impact of CD8+ cells on viral burden based on CD8+ cell frequency or specificity alone give inconsistent results....

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