Aging
CD8+ T-cell replicative senescence modulates age-related pathologies
Published in AIDS Weekly, July 4th, 2005
According to recent research from the United States, "The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. CD8+ T cells that undergo extensive rounds of antigen-driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell-cycle arrest and a critically short telomere length."
R.B. Effros and colleagues, University California Los Angeles, "Cultures...
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Source: AIDS Weekly (2005-07-04)
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