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Genetics and Genomics

Molecular steps involved in the creation of gene-silencing MicroRNAs identified

Published in AIDS Weekly, July 18th, 2005

Researchers have identified the molecular steps involved in the creation of gene-silencing MicroRNAs.

First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for translating genes into proteins.

But how do miRNAs arise' And what can we learn about their biological function from their origins' In a study published last year in Nature, researchers at The Wistar...

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