HIV/AIDS Wasting
NRTI is main determinant of mtDNA depletion in adipose tissue of HIV patients
Published in AIDS Weekly, July 18th, 2005
According to recent research published in the Journal of Clinical Virology, "NRTI-induced host toxicity is proposed to involve cellular mitochondrial DNA (mtDNA) depletion.
"Determinants of cellular mtDNA copy number from HIV-infected patients receiving HAART and HIV-seronegative controls were investigated from subcutaneous fat samples, and relation with antiretroviral regimen was studied."
"HIV-infected patients receiving HAART (n=50), HIV-infected patients not...
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Source: AIDS Weekly (2005-07-18)
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