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HIV/AIDS Pneumococcal Vaccine

HIV-infected children have poorer qualitative antibody responses to PnCV

Published in AIDS Weekly, July 25th, 2005

HIV-infected children have poorer qualitative antibody responses to pneumococcal conjugate vaccine.

In a recently published study, investigators in South Africa conducted a study "to determine the quantitative and qualitative antibody responses to a pneumococcal conjugate vaccine (PnCV) in human immunodeficiency virus (HIV)-exposed infected and uninfected children. Children were randomized to receive either a PnCV or placebo at 6, 10 and 14 weeks of age.

"PnCV serotype-specific antibody concentrations were measured by a standard enzyme immunoassay (EIA) and a 22F modified EIA (22F EIA) on single serum samples drawn at 21-42 days postdose 3....

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