Published in AIDS Weekly, August 1st, 2005
Study 1: Kinetic factors control HIV-1 cell entry efficiency and entry inhibitor efficacy.
According to a study from the United States, "Replication of human immunodeficiency virus type I (HIV-1) in diverse conditions limiting for viral entry into cells frequently leads to adaptive mutations in the V3 loop of the gp120 envelope glycoprotein. This has suggested that the V3 loop limits the efficiencies of HIV-1 infections, possibly by directly affecting gp120-coreceptor affinities.
"In contrast, V3 loop mutations that enable HIV-1(JR-CSF) to use the...
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