HIV/AIDS Pathogenesis

HIV Nef protein promotes survival of infected cells

Published in AIDS Weekly, August 1st, 2005

HIV Nef protein promotes the survival of infected cells.

According to a recent review from India, "The accessory Nef protein is expressed by all primate lentiviruses - HIV-1, HIV-2 and simian immune deficiency virus (SIV).

"Its expression in the early stages of the viral life cycle ensures two basic attributes of HIV infection. These are T-cell activation and the establishment of a persistent state of infection."

"Nef has a positive effect on viral infection and replication by promoting the survival of infected cells. Its role in HIV persistence is based largely on the ability of Nef to downmodulate the surface levels of important...

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Source: AIDS Weekly (2005-08-01)

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