HIV/AIDS-Related Drug Side Effect
Ritonavir affects basal and catecholamine-stimulated lipolysis in adipocytes
Published in AIDS Weekly, August 1st, 2005
"Several of the aspartic acid protease inhibitors used to treat HIV infection increase basal lipolysis in adipocytes, but the cellular mechanisms leading to this augmentation are not well understood.
"We therefore studied the effects of chronic exposure to the HIV protease inhibitor, ritonavir, on the lipolytic cascade in 3T3-L1 adipocytes," researchers in the United States report.
"Treatment of 3T3-L1 adipocytes with ritonavir for 14 d (during and after differentiation) enhanced basal, isoproterenol (Iso)-stimulated, and cAMP analog-stimulated...
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Source: AIDS Weekly (2005-08-01)
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