HIV/AIDS Drug Development
Artificial zinc finger fusions repress HIV-1 transcription and replication
Published in AIDS Weekly, August 8th, 2005
According to a study from South Korea, "Tat activates transcription by interacting with Sp1, NF-kappa B, positive transcription elongation factor b, and trans-activator-responsive element (TAR). Tat and Sp1 play major roles in transcription by protein-protein interactions at human immunodeficiency virus, type 1 (HIV-1) long terminal repeat."
"Sp1 activates transcription by interacting with cyclin T1 in the absence of Tat. To disrupt the transcription activation by Tat and Sp1, we fused Sp1-inhibiting polypeptides, zinc finger polypeptide, and the TAR-binding mutant Tat...
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Source: AIDS Weekly (2005-08-08)
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