HIV/AIDS Drug Development
Peptides derived from HIV-1 RT are inhibitors of the viral integrase
Published in AIDS Weekly, August 15th, 2005
According to recent research from Israel, "Recent studies have shown that the integrase (IN) of HIV-1 is inhibited in vitro by HIV-1 reverse transcriptase (RT).
"We further investigated the specific protein sequences of RT that were involved in this inhibition by screening a complete library of RT-derived peptides for their inhibition of IN activities."
"Two 20-residue peptides, peptide 4286, derived from the RT DNA polymerase domain, and the one designated 4321, from the RT ribonuclease H domain, inhibit the enzymatic activities of IN in...
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Source: AIDS Weekly (2005-08-15)
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