Published in AIDS Weekly, August 22nd, 2005
According to recent research published in the journal Molecular Pharmacology, "The highly conserved Asn136 is in close proximity to the non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI)-specific lipophilic pocket of human immunodeficiency virus type 1 (HIV-1) RT.
"Site-directed mutagenesis has revealed that the catalytic activity of HIV-1 RT mutated at position Asn136 is heavily compromised. Only 0.07 to 2.1% of wild-type activity is retained, depending on the nature of the amino acid change at position 136."
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