HIV/AIDS Drug Development
Amino acid Asn136 of HIV-1 RT enables rational design of RT inhibitors
Published in AIDS Weekly, August 22nd, 2005
According to recent research published in the journal Molecular Pharmacology, "The highly conserved Asn136 is in close proximity to the non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI)-specific lipophilic pocket of human immunodeficiency virus type 1 (HIV-1) RT.
"Site-directed mutagenesis has revealed that the catalytic activity of HIV-1 RT mutated at position Asn136 is heavily compromised. Only 0.07 to 2.1% of wild-type activity is retained, depending on the nature of the amino acid change at position 136."
"The...
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Source: AIDS Weekly (2005-08-22)
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