Published in AIDS Weekly, August 22nd, 2005
Study 1: Researchers report CpG-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate oligodeoxynucleotides and granulocyte-macrophage colony-stimulating factor in elutriated human primary monocytes.
"Chemokines attract leukocytes bearing the relevant chemokine receptors and regulate innate immune responses. CpG oligode-oxynucleotides (ODN) and GM-CSF are potent vaccine adjuvants and in combination induce enhanced Th1 responses by mechanisms yet to be determined. We have examined combinations of CpG-or...
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