HIV/AIDS Pathogenesis
Compartmentalized HIV-1 in cerebrospinal fluid is produced by short-lived cells
Published in AIDS Weekly, August 29th, 2005
"Human immunodeficiency virus type I (HIV-1) invades the central nervous system (CNS) during primary infection and persists in this compartment by unknown mechanisms over the course of infection.
"In this study, we examined viral population dynamics in four asymptomatic subjects commencing antiretroviral therapy to characterize cellular sources of HIV-1 in the CNS," scientists writing in the Journal of Virology report.
"The inability to monitor viruses directly in the brain poses a major challenge in studying HIV-1 dynamics in the CNS.
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Source: AIDS Weekly (2005-08-29)
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