HIV/AIDS Pathogenesis
Research add new data to HIV/AIDS pathogenesis body of knowledge
Published in AIDS Weekly, August 29th, 2005
Study 1: APOBEC3G ubiquitination by HIV-1 Vif-BC-Cul5 is essential for Vif function.
"The human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif) overcomes the antiviral activity of APOBEC3G to protect HIV-1 DNA from G-to-A hypermutation.
"Vif targets APOBEC3G for ubiquitination and proteasomal degradation by forming an SCF-like E3 ubiquitin ligase complex composed of Cullin5, Elongin B, and Elongin C (Vif-BC-Cul5) through a novel SOCS-box motif," scientists in Japan report.
"In this paper," wrote M....
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Source: AIDS Weekly (2005-08-29)
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