Vaccines Adjuvant
Recent findings in vaccines adjuvant provide new insights
Published in AIDS Weekly, August 29th, 2005
Study 1: A recombinant secreted protein of the helminth Onchocerca volvulus, rOv-ASP-1, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide, and SARS-CoV peptide antigens.
"We studied the adjuvanticity of recombinant Onchocerca volvulus activation associated protein-1 (rOv-ASP-1) for ovalbumin (OVA) in mice. After a single immunization and one boost, rOv-ASP-I exceeded the efficacy of alum or MPL + TDM adjuvants in terms of end-point total IgG or IgG1 and IgG2a anti-OVA titers. Using the helminth-derived adjuvant,...
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Source: AIDS Weekly (2005-08-29)
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