HIV/AIDS Research
HIV TAT-Hsp70 protects neurons from nitrosative stress and excitotoxicity
Published in AIDS Weekly, September 12th, 2005
"Induction of heat shock protein 70 (Hsp70) via sublethal stress protects neurons from subsequent lethal injuries. Here we show that specific and efficient intracellular transduction of Hsp70 can be achieved utilizing an 11 amino acid leading sequence from human immunodeficiency virus (TAT-Hsp70) in primary neuronal cultures," researchers in the United States report.
"Western blot and immunohistochemistry demonstrated intracellular accumulation of Hsp70 in insoluble protein fractions and mitochondrial compartments. We then examined the effects of Hsp70 overexpression using...
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Source: AIDS Weekly (2005-09-12)
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