HIV/AIDS Drug Development
Pertussis toxin b-oligomer inhibits HIV infection and replication
Published in AIDS Weekly, September 19th, 2005
According to recent research published in the journal International Immunology, "Bordetella pertussis toxin B-oligomer (PTX-B) has been shown to inhibit HIV infection and replication in vitro."
"The potential antiviral effect of PTX-B was tested here in an in vivo surrogate model of HIV infection, i.e. SCID mice were reconstituted with human peripheral blood leukocytes (PBL) (hu-PBL-SCID) and infected with a CCR5-dependent (R5) HIV-1 strain," stated scientists.
"SCID mice inoculated intraperitoneal (i.p.) with PTX-B and then infected with the R5...
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Source: AIDS Weekly (2005-09-19)
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